| Marise McDermott | President/CEO | 210.357.1924 |
| Robin Brown | Executive Assistant | 210.357.1881 |
| Bea Abercrombie | Chief Administrative Officer | 210.357.1871 |
| Jonathan Miles | Chief of Communications | 210.748.3337 |
| Beth Stricker | Chief Creative Officer | 210.357.1870 |
| Thomas Adams, Ph.D. | Chief Curator & Vice President of Research | 210.357.1852 |
| Helen Holdsworth | Chief of Engagement | 210.357.1890 |
| Vicky Bates | Chief Financial Officer | 210.357.1874 |
| Brady Haynes | Chief of Operations | 210.357.1914 |
| Michelle Everidge, Ph.D. | Chief of Strategic Initiatives | 210.357.1888 |
| Leslie Ochoa | Vice President of Collections | 210.357.1877 |
| Justin Muñoz | Vice President of Development | 210.357.1894 |
| Mendi Etheredge | Vice President of Major Gifts and Endowment | 210.357.1851 |
| Roger Garcia | Vice President of Sales & Events | 210.357.1866 |
| Aimee Spana | Vice President of Visitor Experience | 210.357.1918 |
| Ron Davis | Curator of American History | 210.357.1857 |
| Jennifer Barron, Ph. D. | Curator of Anthropology | 210.357.1868 |
| Harry Shafer, Ph.D. | Curator of Archeology | 210.863.0141 |
| Bruce Shackelford | Texas History Curator | 210.357.1862 |
| Katherine Nelson Hall | Texas Heritage Curator | 210.357.1861 |
| Mary Margaret McAllen | Director of Humanities | 210.357.1856 |
| Cherub Spivey | Director of Reservations and Logistics | 210.357.1913 |
